A new insight into purinergic pharmacology: Three fungal species as natural P2X7R antagonists

Mitophagy: New Insight into the Cardiovascular Aging  

New Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors

  Objective(s): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards FeIII-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide. In this paper the results of a comparative study on the SLO inhibitory activities of the ...

New Insight into the Relation between Adiponectin and Diabetes

Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. Several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. Adiponectin as a 244 amino acid protein is exclusively expressed...

New Insights in Purinergic Therapy: Novel Antagonists for UTP- Activated P2Y Receptors from Natural Products

P2Y2 and P2Y4 receptors are physiologically activated by UTP and are widely expressed in many cell types in humans. They promote an increase in intracellular calcium via PLCβ/ IP3 and act on ion flux and water secretion. P2Y2 plays an important role in inflammation and proliferation of tumor cells, which could be attenuated with the use of antagonists. However, little is known about the physiol...

A new insight into FEIA

Two cases of patients with food and exercise-induced anaphylaxis (FEIA) with confirmed allergies to oral allergy syndrome are herein presented. Patient A had food anaphylaxis to fresh coriander and tomato and Patient B to fresh celery. These food allergens have structural antigenic similarity to that of birch and/or grass. Both patients’ allergies were confirmed by fresh prick-to-prick tests. I...